How to Order Prescriptions
Zycosan is used for the control of clinical signs associated with osteoarthritis in horses.
Dosage and Administration
Administer 3 mg/kg (1.4 mg/lb) by intramuscular injection once weekly.Zycosan is provided in a single use vial and does not contain a preservative. Discard unused vial contents.
Contraindications
Horses with hypersensitivity to pentosan polysulfate sodium or any of the inactive ingredients in Zycosan shouldnot receive Zycosan. Do not use Zycosan concurrently with other anticoagulant drugs. Do not use in horses withclotting disorders or within 24 hours of surgical procedures (see Warnings and Precautions).
Warnings and Precautions
Zycosan has been shown to prolong coagulation parameters up to 24 hours after injection, therefore cautionshould be used when administering this drug before or after strenuous activities (see Target Animal Safety).Due to the anticoagulant effects, this drug may exacerbate Exercise Induced Pulmonary Hemorrhage (EIPH).The concurrent use of NSAIDs with Zycosan has not been evaluated. Due to the anticoagulant effects of Zycosanand known anticoagulant effects of some NSAIDs, caution should be used if NSAIDs are concurrently administered.Horses concurrently treated with Zycosan and NSAIDs should be monitored for hemorrhage or other clinical signsof abnormal bleeding (e.g., petechiae, ecchymosis, or epistaxis).The safety of long-term repeat use of Zycosan has not been evaluated.Pigmentary changes in the retina (pigmentary maculopathy) have been reported in human patients followinglong-term oral use of pentosan polysulfate sodium. It is not known if a similar finding occurs in horses.The safe use of Zycosan has not been evaluated in breeding, pregnant, or lactating horses.
Storage
Store at room temperature 68-77°F (20-25°C), with excursions to 59-86°F (15-30°C).
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