How to Order Prescriptions
CYCLAVANCE is indicated for the control of atopic dermatitis in dogs weighing at least 4 lbs(1.8 kg) body weight. CYCLAVANCE™ (cyclosporine oral solution) USP MODIFIED is an oral form of cyclosporinethat immediately forms a microemulsion in an aqueous environment. Cyclosporine, the active ingredient inCYCLAVANCE, is a cyclic polypeptide, immune modulating agent consisting of 11 amino acids. It is producedas a metabolite by the fungal species Beauveria nivea.
Dosage and Administration
Always Provide the Instructions for Assembling the Dispensing Systemand Preparing a Dose of CYCLAVANCE and the Information for Dog Owners with the prescription. Theinitial dose of CYCLAVANCE is 5 mg/kg/day as a single daily dose for 30 days. Following this initial dailytreatment period, the dose of CYCLAVANCE may be tapered by decreasing the frequency of dosing to everyother day or twice weekly, until a minimum frequency is reached which will maintain the desired therapeuticeffect. CYCLAVANCE should be given at least one hour before or two hours after a meal. If a dose is missed,the next dose should be administered (without doubling) as soon as possible but dosing should be no morefrequent than once daily. The dispensing system for the 5 and 15 mL vial sizes includes a 1 mL oral dosingsyringe graduated in 0.05 mL increments. To dose the dog, administer 0.05 mL of CYCLAVANCE per 2.2 lbs ofbody weight. The dispensing system for the 30 and 50 mL vial sizes includes both a 1 mL oral dosing syringegraduated in 0.05 mL increments, and a 3 mL oral dosing syringe graduated in 0.1 mL increments. To dosethe dog, administer 0.1 mL of CYCLAVANCE per 4.4 lbs of body weight. Do not rinse or clean the oral dosingsyringe between uses. (See Instructions for Assembling the Dispensing System and Preparing a Dose ofCYCLAVANCE.)
Assembling the Dispensing System
The dispensing system consists of three parts:
- A vial containing the medicine sealed with a rubber stopper
- A plastic adapter (dispensing system) that you will push onto the top of the vial. The adapter must always remain on the vial after first use.
- An oral dosing syringe that fits into the top of the plastic adapter to withdraw the prescribed dose of medicine from the vial. (1 mL syringe with the 5 and 15 mL vial sizes; 1 and 3 mL syringes with the 30 and 50 mL vial sizes)
